Description | Specificity: CD28 costimulatory receptor, Mr 40 kDa. CD28 is a type I disulfide-linked homodimer that is constitutively expressed on most thymocytes, at low density on nearly all CD4^+ and CD8^+ peripheral T lymphocytes, and at very low levels on NK cells. Its expression is upregulated upon T-cell activation.^1-4 CD28 is a ligand for CD80/B7-1 and CD86/B7-2 on B cells and other antigen presenting cells, and plays an important role in the interaction between T cells and B cells. CD28 is a co-stimulatory receptor involved in many, but not all, T-cell independent immune responses.^5-8. |
Product Specific References | 1. Gross, J. A., E. Callas, and J. P. Allison. 1992. J. Immunol. 149:380.2. Giese, T., J. P. Allison, and W. F. Davidson. 1993. J. Immunol. 151:597.3. Clements, J. L., G. Winslow, C. Donahue, S. M. Cooper, J. P. Allison, and R. C. Budd. 1993. Int. Immunol. 5:1451.4. Nandi, D., J. A. Gross, and J. P. Allison. 1994. J. Immunol. 152:3361.5. June, C.H., J.A. Bluestone, L.M. Nadler, and C.B. Thompson. 1992. Immunol. Today 15:321.6. Gelfanov, V., Y. G. Lai, V. Gelfanova, J. Y. Dong, J. P. Su, and N. S. Liao. 1995. J. Immunol. 155:76.7. Harding, F. A., J. G. McArthur, J. A. Gross, D. H. Raulet, and J. P. Allison. 1992. Nature 356:607.8. Bluestone, J.A. 1995. Immunity 2:555. |