Piccolo Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityPiccolo
Clone[6H9-B6]
Host SpeciesMouse
Reactive Specieshuman, rat
IsotypeIgG2b kappa
FormatATTO 680 conjugate
Size0.1 mg
Concentration1mg/mL
ApplicationsWestern Blot (WB), ELISA (EIA)
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DescriptionBackground Info: No cross-reactivity to Bassoon, band at ~550kDa correspondng to the molecular weight of Piccolo. Scientific Background: Piccolo, also referred to as Aczonin, is a large protein which consists of an N-terminal Zn2 finger, several piccolo-bassoon homology domains and C-terminal PDZ and C2 domains (1, 2). In general it is found together with bassoon, a related huge multi-domain protein of the CAZ (cytoskeletal matric assembled at active zones) (3). Piccolo is a scaffolding protein for proteins involved in endo- and exocytosis of synaptic vesicles. Piccolo has also been shown to interfere with clathrin medicated endocytosis by binding to the F-actin and dynamin binding protein Abp1 (2).
Immunogenn/a
Other Names[ACZ; Aczonin; PCLO; Pico; presynaptic cytomatrix protein], [Pclo; Pclo; Acz; Pico; Acz]
Gene, Accession #Gene ID: 26875, NCBI: NP_001104266.1, UniProt: Q9QYX7
Catalog #MBS800013
Price$430
Order / More InfoPiccolo Antibody from MYBIOSOURCE INC.
Product Specific References1. Gerber S.H., Garcia J., Rizo J., Sudhof T.C. (2001) EMBO J. 20(7): 1605-1619. 2. Wang X., et al. (1999) J Cell Biol. 147(1): 151-162. 3. Dresbach T., et al. (2006) J Biol Chem. 281(9):6038- 6047.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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