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Antigenic Specificity | Piccolo |
Clone | [6H9-B6] |
Host Species | Mouse |
Reactive Species | human, rat |
Isotype | IgG2b kappa |
Format | ATTO 680 conjugate |
Size | 0.1 mg |
Concentration | 1mg/mL |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background Info: No cross-reactivity to Bassoon, band at ~550kDa correspondng to the molecular weight of Piccolo. Scientific Background: Piccolo, also referred to as Aczonin, is a large protein which consists of an N-terminal Zn2 finger, several piccolo-bassoon homology domains and C-terminal PDZ and C2 domains (1, 2). In general it is found together with bassoon, a related huge multi-domain protein of the CAZ (cytoskeletal matric assembled at active zones) (3). Piccolo is a scaffolding protein for proteins involved in endo- and exocytosis of synaptic vesicles. Piccolo has also been shown to interfere with clathrin medicated endocytosis by binding to the F-actin and dynamin binding protein Abp1 (2). |
Immunogen | n/a |
Other Names | [ACZ; Aczonin; PCLO; Pico; presynaptic cytomatrix protein], [Pclo; Pclo; Acz; Pico; Acz] |
Gene, Accession # | Gene ID: 26875, NCBI: NP_001104266.1, UniProt: Q9QYX7 |
Catalog # | MBS800013 |
Price | $430 |
Order / More Info | Piccolo Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Gerber S.H., Garcia J., Rizo J., Sudhof T.C. (2001) EMBO J. 20(7): 1605-1619. 2. Wang X., et al. (1999) J Cell Biol. 147(1): 151-162. 3. Dresbach T., et al. (2006) J Biol Chem. 281(9):6038- 6047. |