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Antigenic Specificity | Epithelial cell adhesion molecule, EP-CAM |
Clone | [3-E1-E2] |
Host Species | Mouse |
Reactive Species | human, mouse |
Isotype | IgM |
Format | Protein A purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Epithelial cell adhesion molecule (Ep-CAM) is a pan-epithelial differentiation antigen. [1]It is intricately linked with the Cadherin-Catenin pathway and hence the fundamental WNT pathway responsible for intracellular signalling and polarity. It has been used as an immunotherapeutic target in the treatment of gastrointestinal, urological and other carcinomas. [2]It is expressed in undifferentiated pluripotent stem cells. [3] and it is being used as a target for immunotherapy treatment of human carcinomas. |
Immunogen | Immunogen: Recombinant EP-CAM protein. |
Other Names | [Epithelial cell adhesion molecule; EP-CAM], [EPCAM; EPCAM; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1; GA733-2; M1S2; M4S1; MIC18; TACSTD1; TROP1; Ep-CAM; EGP; EGP314; hEGP314] |
Gene, Accession # | [EP-CAM], Gene ID: 4072, NCBI: AAH14785.1, UniProt: P16422 |
Catalog # | MBS355089 |
Price | $275 |
Order / More Info | Epithelial cell adhesion molecule, EP-CAM Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Calabrese G, Crescenzi C, Morizio E, Palka G, Guerra E, Alberti S (Apr 2001). Assignment of TACSTD1 (alias TROP1, M4S1) to human chromosome 2p21 and refinement of mapping of TACSTD2 (alias TROP2, M1S1) to human chromosome 1p32 by in situ hybridization. Cytogenet Cell Genet 92 (1-2): 164-5. 2. Chaudry MA, Sales K, Ruf P, Lindhofer H, Winslet MC (April 2007). EpCAM an immunotherapeutic target for gastrointestinal malignancy: current experience and future challenges. Br. J. Cancer 96 (7): 1013-9. 3. Sundberg, M; Jansson, L; Ketolainen, J; Pihlajamaki, H; Suuronen, R; Skottman, H; Inzunza, J; Hovatta, O et al. (2009). CD marker expression profiles of human embryonic stem cells and their neural derivatives, determined using flow-cytometric analysis, reveal a novel CD marker for exclusion of pluripotent stem cells.. Stem cell research 2 (2): 113-24. |