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Antigenic Specificity | PYCARD |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, rat |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.06 mL, 0.12 mL, 0.2 mL |
Concentration | 1mg/mL |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | TMS1 (target of methylation-induced silencing)/ASC (apoptosis-associated speck-like protein containing a CARD), also referred to as PYCARD and CARD5, is a 22-kDa pro-apoptotic protein containing an N-terminal pyrin domain (PYD) and a C-terminal caspase recruitment domain (CARD) (1-2). The TMS1 gene was originally found to be aberrantly methylated and silenced in breast cancer cells (2), and has since been found to be silenced in a number of other cancers, including ovarian cancer (3), glioblastoma (4), melanoma (5), gastric cancer (6), lung cancer (7), and prostate cancer (8). Expression of TMS1 can be induced by pro-apoptotic/inflammatory stimuli (9). During apoptosis TMS1 is re-distributed from the cytosol to the mitochondria and associat |
Immunogen | Immunogen: Recombinant protein of human PYCARD Observed Molecular Weight: 25kDa |
Other Names | [PYCARD; ASC; CARD5; MGC10332; TMS; TMS-1; TMS1] |
Gene, Accession # | [PYCARD], Gene ID: 29108, NCBI: AAG30286.1 |
Catalog # | MBS2519855 |
Price | $150, $225, $360 |
Order / More Info | PYCARD Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |