TAU, Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-TAU, antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | TAU, |
| Clone | polyclonal |
| Host Species | n/a |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Immunocytochemistry (ICC), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Tau is a heterogeneous microtubule-associated protein that promotes and stabilizes microtubule assembly, especially in axons. Six isoforms with different amino-terminal inserts and different numbers of tandem repeats near the carboxy-terminus have been identified, and tau is hyperphosphorylated at approximately 25 sites by ERK, GSK-3 and CDK5. Phosphorylation decreases the ability of tau to bind to microtubules. Neurofibrillary tangles are a major hallmark of Alzheimer's disease and these tangles are bundles of paired helical filaments composed of hyperphosphorylated tau. In particular, phosphorylation of Ser396 by GSK-3 or CDK5 destabilizes microtubules in Alzheimer's disease. Furthermore, inclusions of tau are found in a number of other n |
| Immunogen | Immunogen: Chicken synthetic peptide/keyhole limpet hemocyanin (KLH) conjugates corresponding to two regions of the Tau gene product. These peptides corresponded to sequences shared between the mouse (P01637) and human (NP 05819) proteins, and did not contain any of the serine and threonine residues known to undergo phosphorylation. |
| Other Names | [TAU, partial; Microtubule-associated protein], [TAU] |
| Gene, Accession # | [Tau], NCBI: JAO90068.1 |
| Catalog # | MBS555375 |
| Price | $190 |
| Order / More Info | TAU, Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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