Mouse Trib3 (C-term), 306-334 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Mouse Trib3 (C-term), 306-334 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse |
| Isotype | n/a |
| Format | peptide affinity purified |
| Size | 0.08 mL, 0.4 mL |
| Concentration | vial concentration: 0.5 |
| Applications | Western Blot (WB), ELISA (EIA) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This Mouse Trib3 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 306-334 amino acids from the C-terminal region of mouse Trib3. Trib3 disrupts insulin signaling by binding directly to Akt kinases and blocking their activation. May bind directly to and mask the 'Thr-308' phosphorylation site in AKT1. Binds to ATF4 and inhibits its transcriptional activation activity. Interacts with the NF-kappa-B transactivator p65 RELA and inhibits its phosphorylation and thus its transcriptional activation activity. Interacts with MAPK kinases and regulates activation of MAP kinases. May play a role in programmed neuronal cell death but does not appear to affect non-neuronal cells. Does not display kinase activi |
| Immunogen | n/a |
| Other Names | [Tribbles homolog 3; TRB-3; Neuronal cell death-inducible putative kinase; Trib3; Nipk; Trb3] |
| Gene, Accession # | [Trib3], Gene ID: 228775, NCBI: NP_780302.2, UniProt: Q8K4K2 |
| Catalog # | MBS9209520 |
| Price | $165, $370 |
| Order / More Info | Mouse Trib3 (C-term), 306-334 Antibody from MYBIOSOURCE INC. |
| Product Specific References | Morse, E., et al. Am. J. Physiol. Renal Physiol. 299 (5), F965-F972 (2010) : Dedhia, P.H., et al. Blood 116(8):1321-1328(2010) Liew, C.W., et al. J. Clin. Invest. 120(8):2876-2888(2010) Humphrey, R.K., et al. J. Biol. Chem. 285(29):22426-22436(2010) Liu, J., et al. Am. J. Physiol. Endocrinol. Metab. 298 (3), E565-E576 (2010) : |
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