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Antigenic Specificity | SPPL2a (N-term), 108-138 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 2 |
Applications | Western Blot (WB), ELISA (EIA), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This SPPL2a antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 108-138 amino acids from the N-terminal region of human SPPL2a. By searching sequence databases for homologs of Dictyostelium discoideum Impas, which shares homology with presenilin, followed by PCR of lymphocyte and hippocampus cDNA libraries, Grigorenko et al. (2002) cloned SPPL2a. This protein, which may act as an intramembrane protease, contains an N-terminal protease-associated (PA) domain, several transmembrane regions, a hydrophilic loop, conservative sequences around the first and second aspartate residues, and an invariant PAL motif near the C terminus. |
Immunogen | n/a |
Other Names | [Signal peptide peptidase-like 2A; SPP-like 2A; SPPL2a; 3423-; Intramembrane protease 3; IMP-3; Presenilin-like protein 2; SPPL2A; IMP3; PSL2] |
Gene, Accession # | [SPPL2A], Gene ID: 84888, NCBI: NP_116191.2, UniProt: Q8TCT8 |
Catalog # | MBS9201943 |
Price | $165, $370 |
Order / More Info | SPPL2a (N-term), 108-138 Antibody from MYBIOSOURCE INC. |
Product Specific References | Grigorenko, A. P., et al. Biochemistry 67: 826-834 (2002). |