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Antigenic Specificity | EMAP-II, Human |
Clone | 546-2 |
Host Species | Mouse |
Reactive Species | reactivity: human. cross reactivity: rat |
Isotype | IgG2b |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), Immunoassay (IA), P, Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Product Description: Monoclonal antibody 546-2 reacts with endothelial-monocyte-activating polypeptide II (EMAP II), a 20 kDa polypeptide. EMAP II is an antiangiogenic and proinflammatory cytokine (expressed by microglia/macrophages). EMAP II appears to be a profound modulator of inflammatory reactions of the innate immune system and might participate in a variety of pathogenic immune-processes in the mammalian brain. EMAP II is a potential mediator of inflammatory responses in autoimmunity and a considered target to stage reactions of monocytic lineage cells in inflammatory reactions. In normal tissues EMAP II is expressed in endocrine organs, in cells of neuroendocrine origin, but also in tissues with high cell turnover. Under pathophysio |
Immunogen | n/a |
Other Names | [endothelial-monocyte activating polypeptide II; Aminoacyl tRNA synthase complex-interacting multifunctional protein 1; aminoacyl tRNA synthase complex-interacting multifunctional protein 1; ARS-interacting multifunctional protein 1; endothelial monocyte-activating polypeptide 2; multisynthase complex auxiliary component p43; endothelial-monocyte activating polypeptide II; multisynthetase complex auxiliary component p43; small inducible cytokine subfamily E, member 1 (endothelial monocyte-activating); aminoacyl tRNA synthetase complex-interacting multifunctional protein 1; Multisynthase complex auxiliary component p43Cleaved into the following chain:Endothelial monocyte-activating polypeptide 2; EMAP-2Alternative name(s):Endothelial monocyte-activating polypeptide II; EMAP-II; Small inducible cytokine subfamily E member 1], [AIMP1; AIMP1; p43; HLD3; EMAP2; SCYE1; EMAPII; EMAP2; SCYE1; EMAP-2; EMAP-II] |
Gene, Accession # | [EMAP-II], Gene ID: 9255, NCBI: AAA62202.1 |
Catalog # | MBS584124 |
Price | $520 |
Order / More Info | EMAP-II, Human Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Mueller, C et al; Accumulation of the proinflammatory cytokine endothelial-monocyte-activating polypeptide II in ramified microglial cells in brains of Borna virus infected Lewis rats. Neurosci Lett 2003, 339: 215 2. Mueller, C et al; Lesional expression of a proinflammatory and antiangiogenic cytokine EMAP II confined to endothelium and microglia/macrophages during secondary damage following experimental traumatic brain injury. J Neuroimmunol 2003, 135: 1 3. Mueller, C et al; Spinal cord injury induces lesional expression of the proinflammatory and antiangiogenic cytokine EMAP II. J Neurotrauma 2003, 20: 1007 4. Schluesener, H et al; Localization of endothelial-monocyte-activating polypeptide II (EMAP II), a novel proinflammatory cytokine, to lesions of experimental autoimmune encephalomyelitis, neuritis, and uveitis: expression by monocytes and activated microglial cells. Glia 1997, 20: 365 |