Edit |   |
---|---|
Antigenic Specificity | Acetylated Lysine |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | Multi species |
Isotype | n/a |
Format | peroxidase (HRP) conjugate |
Size | 0.4 mL |
Concentration | 0.25mg/mL |
Applications | Western Blot (WB), ELISA (EIA), Immunoprecipitation (IP), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Background Info: Detects proteins containing acetylated lysine residues in SDS PAGE immunoblots. Scientific Background: Post-translational modifications of proteins play critical roles in the regulation and function of many known biological processes. Proteins can be post-translationally modified in many different ways, and a common post-transcriptional modification of Lysine involves acetylation (1). The conserved amino-terminal domains of the four core histones (H2A, H2B, H3 and H4) contain lysines that are acetylated by histone acetyltransferases (HATs) and deacetylated by histone deacetylases (HDACs) (2). Protein posttranslational reversible lysine Nepsilon-acetylation and deacetylation have been recognized as an emerging intracellular |
Immunogen | n/a |
Other Names | n/a |
Gene, Accession # | n/a |
Catalog # | MBS805559 |
Price | $460 |
Order / More Info | Acetylated Lysine Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Yang XJ. (2005). Oncogene. 24:1653-1662. 2. Hassig, C.A. and Schreiber, S.L. (1997). Curr. Opin. Chem. Biol. 1(3): 300-308. 3. Yang XJ. (2004). Bioessays 26:1076-1087. 4. Hughes, R.E. (2002). Curr. Biol. 12: R141-R143. 5. Vigushin, D.M. and Coombes, R.C. (2004). Curr. Cancer Drug Targets 4: 205-218. 6. Chan, H.M. et al. (2001). Nat. Cell Biol. 3: 667-. 674. 7. Martinez-Balbas, M.A. et al. (2000). EMBO J. 19: 662-671. |