CDK4 Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityCDK4
Clonemonoclonal
Host SpeciesMouse
Reactive Specieshuman, mouse
IsotypeIgG1
Formataffinity purified
Size0.1 mg
Concentrationn/a
ApplicationsWestern Blot (WB)
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DescriptionThis antibody detects endogenous levels of CDK4 and does not cross-react with related proteins. UniPort Summary Function: Ser/Thr-kinase component of cyclin D-CDK4 (DC) complexes that phosphorylate and inhibit members of the retinoblastoma (RB) protein family including RB1 and regulate the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complexes and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also phosphorylates SMAD3 in a cell-cycle-dependent manner and repre
ImmunogenImmunogen: Purified recombinant human CDK4 protein fragments expressed in E Coli. Cellular Localization: Cytoplasm; Nucleus; Membrane
Other Names[Cell division protein kinase 4 PSK-J3], [CMM3; PSK-J3]
Gene, Accession #[CDK4], Gene ID: 1019, NCBI: NP_000066.1, UniProt: P11802
Catalog #MBS857746
Price$300
Order / More InfoCDK4 Antibody from MYBIOSOURCE INC.
Product Specific Referencesn/a
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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