Unphosphorylated N-Cadherin (Tyr-820) Antibody from MYBIOSOURCE INC.

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Antigenic SpecificityUnphosphorylated N-Cadherin (Tyr-820)
Clonepolyclonal
Host SpeciesRabbit
Reactive Specieshuman, rat, mouse
Isotypen/a
Formataffinity purified
Size0.1 mL
Concentrationn/a
ApplicationsELISA, Western Blot
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DescriptionThis antibody was cross-adsorbed to phospho-Ncadherin (Tyr-820) peptide before affinity purification using unphosphorylated N-cadherin (Tyr-820) peptide. The purified antibody detects a strong band at 130 kDa* in western blots of serum-starved human endothelial cells, but is decreased in pervanadate treated cells. This reactivity in western blots is blocked specifically by unphosphorylated N-cadherin (Tyr-820) peptide. Cadherins are transmembrane glycoproteins vital in calcium-dependent cell-cell adhesion during tissue differentiation. Cadherins cluster to form foci of homophilic binding units. A key determinant to the strength of the cadherin-mediated adhesion may be by the juxtamembrane region in cadherins. This region induces clustering
ImmunogenImmunogen: Unphosphorylated N-Cadherin (Tyr-820) synthetic peptide (coupled to carrier protein) corresponding to amino acids surrounding tyrosine 820 inhuman N-cadherin. This sequence is conserved in rat and mouse Ncadherin, and has three amino acid differences from the conserved region in R-cadherin.
Other Namesn/a
Gene, Accession #n/a
Catalog #MBS472063
Price$385
Order / More InfoUnphosphorylated N-Cadherin (Tyr-820) Antibody from MYBIOSOURCE INC.
Product Specific References• Xu, Y. et al. (1997) J. Biol. Chem. 272(21):13463• Xu, Y. & Carpenter, G. (1999) J. Cell. Bioch. 75:264.• Qi, J. et al. (2006) Mol. Biol. Cell 17(3):1261.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166

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