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Antigenic Specificity | Mouse CD119 |
Clone | [GR-20] |
Host Species | Rat |
Reactive Species | mouse |
Isotype | IgG2a |
Format | unconjugated |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | CDw119 is a 90 kD immunoglobulin superfamily member, also known as IFN-gammaRalpha chain. It is a class II cytokine receptor family member that serves as a IFN-gamma-binding chain associated with the IFN-gamma beta chain also known as AF-1. In addition to ligand binding, CDw119 participates in ligand trafficking. CDw119 is expressed on T and B cells, NK cells, fibroblasts, endothelial, and epithelial cells. Binding of IFN-gamma induces receptor dimerization, internalization, Jak1 and Jak2 protein kinase activation and, ultimately, STAT1 activation. IFN-gamma initiates and regulates a variety of immune responses. |
Immunogen | n/a |
Other Names | [Mouse CD119; Interferon gamma receptor 1; Ifngr1; IFN-gamma-R1; IFN-gamma-R-alpha; CD119] |
Gene, Accession # | [CD119], Gene ID: 15979, NCBI: NP_034641.1, UniProt: P15261 |
Catalog # | MBS2553979 |
Price | $100, $115 |
Order / More Info | Mouse CD119 Antibody from MYBIOSOURCE INC. |
Product Specific References | 1. Basu M, et al. 1988. P. Natl. Acad. Sci. USA 85:6282. 2. Codias EK, et al. 1990. J. Immunol. 144:2197. |