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Antigenic Specificity | Phospho-SMAD2 (S250) |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | IgG |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator. |
Immunogen | Immunogen: A synthesized peptide derived from human Phospho-SMAD2 (S250) |
Other Names | [Mothers against decapentaplegic homolog 2; MAD homolog 2; Mothers against DPP homolog 2; JV18-1; Mad-related protein 2; hMAD-2; SMAD family member 2; SMAD 2; Smad2; hSMAD2; SMAD2; MADH2; MADR2] |
Gene, Accession # | [SMAD2], Gene ID: 4087, NCBI: NP_001003652.1, UniProt: Q15796 |
Catalog # | MBS7114923 |
Price | $185, $265 |
Order / More Info | Phospho-SMAD2 (S250) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |