hnRNP K Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | hnRNP K |
| Clone | monoclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.03 mg, 0.1 mg, 0.1 mg |
| Concentration | n/a |
| Applications | Immunoprecipitation (IP), Immunofluorescence (IF), Immunohistochemistry (IHC), Immunocytochemistry (ICC), Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | One of the major pre-mRNA-binding proteins. Binds tenaciously to poly(C) sequences. Likely to play a role in the nuclear metabolism of hnRNAs, particularly for pre-mRNAs that contain cytidine-rich sequences. Can also bind poly(C) single- stranded DNA. Plays an important role in p53/TP53 response to DNA damage, acting at the level of both transcription activation and repression. When sumoylated, acts as a transcriptional coactivator of p53/TP53, playing a role in p21/CDKN1A and 14-3-3 sigma/SFN induction (By similarity). As far as transcription repression is concerned, acts by interacting with long intergenic RNA p21 (lincRNA-p21), a non-coding RNA induced by p53/TP53. This interaction is necessary for the induction of apoptosis, but not cel |
| Immunogen | Immunogen: A synthesized peptide derived from human hnRNP K. Subcellular Localization: Cytoplasm. Nucleus, nucleoplasm. Cell projection, podosome. Recruited to p53/TP53- responsive promoters, in the presence of functional p53/TP53 (PubMed: 16360036). In case of ASFV infection, there is a shift in the localization which becomes predominantly nuclear (PubMed: 18775702). |
| Other Names | [Heterogeneous nuclear ribonucleoprotein K; hnRNP K; Transformation up-regulated nuclear protein; TUNP; HNRNPK; HNRPK], [HNRNPK; HNRNPK; AUKS; CSBP; TUNP; HNRPK; HNRPK; hnRNP K; TUNP] |
| Gene, Accession # | [HNRNPK], Gene ID: 3190, NCBI: NP_001305115.1, UniProt: P61978 |
| Catalog # | MBS179737 |
| Price | $160, $340, $340 |
| Order / More Info | hnRNP K Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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