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Antigenic Specificity | Mouse Ring1 (C-term) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse |
Isotype | n/a |
Format | purified |
Size | 0.08 mL, 0.4 mL |
Concentration | vial concentration: 0.377 |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This Mouse Ring1 antibody is generated from a rabbit immunized with a KLH conjugated synthetic peptide between 306-340 amino acids from the C-terminal region of human Mouse Ring1. Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex a |
Immunogen | n/a |
Other Names | [E3 ubiquitin-protein ligase RING1; 632-; Polycomb complex protein RING1; RING finger protein 1; Transcription repressor Ring1A; Ring1; Ring1A; Rnf1] |
Gene, Accession # | [Ring1], Gene ID: 19763, NCBI: NP_033092.3, UniProt: O35730 |
Catalog # | MBS9215323 |
Price | $165, $370 |
Order / More Info | Mouse Ring1 (C-term) Antibody from MYBIOSOURCE INC. |
Product Specific References | Schoorlemmer J.,et al.EMBO J. 16:5930-5942(1997). Rowen L.,et al.Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases. Carninci P.,et al.Science 309:1559-1563(2005). Ebert L.,et al.Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases. de Napoles M.,et al.Dev. Cell 7:663-676(2004). |