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Antigenic Specificity | INDO |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total INDO antibody. INDO/IDO1/indoleamine 2,3-dioxygenase (IDO) is an IFN-g-inducible enzyme that catalyzes the rate-limiting step of tryptophan degradation (1). IDO is upregulated in many tumors and in dendritic cells in tumor-draining lymph nodes. Elevated tryptophan catabolism in these cells leads to tryptophan starvation of T cells, limiting T cell proliferation and activation (2). Therefore, IDO is considered an immunosuppresive molecule, and research studies have shown that upregulation of IDO is a mechanism of cancer immune evasion (3). The gastrointestinal stromal tumor drug, imatinib, was found to act, in part, by reducing IDO expression, resulting in increased CD8+ T cell activation and in |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human INDO. |
Other Names | [CD107B; IDO; INDO] |
Gene, Accession # | [INDO], Gene ID: 3620, NCBI: NP_002155.1, UniProt: P14902 |
Catalog # | MBS9404087 |
Price | $255 |
Order / More Info | INDO Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |