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Antigenic Specificity | NGEF |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.1 mL |
Concentration | 0.6 mg/mL |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total NGEF protein. Acts as a guanine nucleotide exchange factor (GEF) which differentially activates the GTPases RHOA, RAC1 and CDC42. Plays a role in axon guidance regulating ephrin-induced growth cone collapse and dendritic spine morphogenesis. Upon activation by ephrin through EPHA4, the GEF activity switches toward RHOA resulting in its activation. Activated RHOA promotes cone retraction at the expense of RAC1- and CDC42-stimulated growth cone extension (By similarity). |
Immunogen | Immunogen: Fusion protein of human NGEF Immunogen Type: Peptide |
Other Names | [EPHEXIN; ARHGEF27] |
Gene, Accession # | [NGEF], Gene ID: 25791, NCBI: NP_001107562.1, UniProt: Q8N5V2 |
Catalog # | MBS9430299 |
Price | $255 |
Order / More Info | NGEF Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |