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Antigenic Specificity | TRADD |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous level of total TRADD protein. Apoptosis mediated by death factors like FasL and TNF-a involves the formation of a death-inducing signaling complex (DISC) to their respective receptors (1). Upon ligand activation to their receptors, Fas and TNF-R1 associate with death domain (DD) containing adaptor proteins FADD (Fas associated death domain) (2,3) and TRADD (TNF-R1 associated death domain) (4). In addition to its carboxy-terminal DD, FADD contains an amino-terminal death effector domain (DED) that binds to DEDs found on caspase-8 which leads to activation of this initiator caspase (5,6). Caspase-8 subsequently activates downstream effector caspases, like caspase-3, resulting in the cleavage of proteins involve |
Immunogen | Immunogen Type: Recombinant Protein Immunogen Description: Recombinant protein of human TRADD. |
Other Names | [TRADD; Hs.89862; MGC11078] |
Gene, Accession # | [TRADD], Gene ID: 8717, NCBI: NP_003780.1, UniProt: Q15628 |
Catalog # | MBS9406680 |
Price | $255 |
Order / More Info | TRADD Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |