CONNEXIN 43 (pSer368) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | CONNEXIN 43 (pSer368) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | bovine (expected from sequence), chicken (expected from sequence), dog (expected from sequence), guinea pig (expected from sequence), human (expected from sequence), mouse (expected from sequence), zebrafish (expected from sequence) |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB)* |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | This item specifically recognises 43kDa Connexin43, when phosphorylated at Ser368. Connexin43 (CX43) allows for the exchange of solutions between neighbouring cells through the formation of gap-junctional channels and is expressed in the brain, kidneys and myocardium, as well as vascular endothelial cells. Studies suggest that a decrease in the permeability of gap-junctional channels occurs due to a conformational change in the structure of CX43, and that this is mediated by the phosphorylation of CX43 at residue Ser368, by Protein Kinase C (PKC). A possible link between CX43 and epilepsy has been investigated following the detection of high levels of CX43 in both low-grade tumours and peritumoural reactive astrocytes, see Aronica, E. et al |
| Immunogen | Immunogen: Synthetic phosphopeptide corresponding to an amino acid sequence within connexin43 which includes phosphorylated Ser368 Buffer Solution: 10mM HEPES pH7.5 Antiserum Preparation: Antisera to rat connexin43 were raised by repeated immunisations of rabbits with highly purified antigen. Purified IgG was prepared by affinity chromatography. Target Species: Rat |
| Other Names | [gap junction alpha-1 protein; Gap junction alpha-1 protein; gap junction alpha-1 protein; connexin 43; connexin-43; gap junction 43 kDa heart protein; gap junction membrane channel protein alpha 1; gap junction protein, alpha 1; Connexin-43; Cx43; Gap junction 43 kDa heart protein], [Gja1; Gja1; Cx43; Cxn-43; Cx43] |
| Gene, Accession # | Gene ID: 24392, NCBI: NP_036699.1, UniProt: P08050 |
| Catalog # | MBS223268 |
| Price | $550 |
| Order / More Info | CONNEXIN 43 (pSer368) Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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