Edit |   |
---|---|
Antigenic Specificity | CSE1L |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.05 mL, 0.1 mL, 0.2 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Proteins that carry a nuclear localization signal (NLS) are transported into the nucleus by the importin-alpha/beta heterodimer. Importin-alpha binds the NLS, while importin-beta mediates translocation through the nuclear pore complex. After translocation, RanGTP binds importin-beta and displaces importin-alpha. Importin-alpha must then be returned to the cytoplasm, leaving the NLS protein behind. The protein encoded by this gene binds strongly to NLS-free importin-alpha, and this binding is released in the cytoplasm by the combined action of RANBP1 and RANGAP1. In addition, the encoded protein may play a role both in apoptosis and in cell proliferation. Alternatively spliced transcript variants have been found for this gene. |
Immunogen | Immunogen: Recombinant protein of human CSE1L |
Other Names | [CAS; CSE1; XPO2] |
Gene, Accession # | [CSE1L], Gene ID: 1434, NCBI: NP_001243064.1, UniProt: P55060 |
Catalog # | MBS9129118 |
Price | $200, $275, $430 |
Order / More Info | CSE1L Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |