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Antigenic Specificity | Human SOCS-3 |
Clone | [SO1] |
Host Species | Mouse |
Reactive Species | n/a |
Isotype | IgG2b |
Format | unconjugated |
Size | 0.1 mg |
Concentration | Ig concentration 1.0 mg/ml |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Mouse anti Human SOCS-3 antibody, clone SO1 recognizes the human suppressor of cytokine signaling 3 protein, also known as SOCS-3, cytokine-inducible SH2 protein 3 or STAT-induced STAT inhibitor 3. SOCS-3 is a 225 amino acid, 30kDa member of the suppressor of cytokine signaling family (Starr et al. 1997) containing a single SH2 and a single SOCS box domain. SOCS-3 acts as a negative regulator of Janus Kinase (JAK) and signal transducer and activators of transcription (STAT) signaling pathways. SOCS-3 specifically acts as a negative feedback regulator for the STAT3 pathways, by directly binding to the Tyr-759 motif of the IL-6 signal-transducing receptor subunit gp130, thereby preventing the IL-6 activation of STAT3. The expression of SOCS-3 |
Immunogen | n/a |
Other Names | [suppressor of cytokine signaling 3; Suppressor of cytokine signaling 3; suppressor of cytokine signaling 3; STAT-induced STAT inhibitor 3; cytokine-inducible SH2 protein 3; suppressor of cytokine signaling 3; Cytokine-inducible SH2 protein 3; CIS-3; STAT-induced STAT inhibitor 3; SSI-3], [SOCS3; SOCS3; CIS3; SSI3; ATOD4; Cish3; SSI-3; SOCS-3; CIS3; SSI3; SOCS-3; CIS-3; SSI-3] |
Gene, Accession # | [SOCS-3], Gene ID: 9021, NCBI: NP_003946.3, UniProt: O14543 |
Catalog # | MBS212753 |
Price | $300 |
Order / More Info | Human SOCS-3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |