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Antigenic Specificity | Human TAR DNA-binding protein 43 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | antigen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | DNA and RNA-binding protein which regulates transcription and splicing. Involved in the regulation of CFTR splicing. It promotes CFTR exon 9 skipping by binding to the UG repeated motifs in the polymorphic region near the 3'-splice site of this exon. The resulting aberrant splicing is associated with pathological features typical of cystic fibrosis. May also be involved in microRNA biogenesis, apoptosis and cell division. Can repress HIV-1 transcription by binding to the HIV-1 long terminal repeat. Stabilizes the low molecular weight neurofilament (NFL) mRNA through a direct interaction with the 3' UTR. |
Immunogen | Immunogen: Recombinant human TARDBP protein (1-260aa) Santa Cruz Alternative: Potential replacement for Santa Cruz Biotechnology antibody catalog# sc-102127 / sc-292299 |
Other Names | [TDP-43; TARDBP; TDP43], [TARDBP; TARDBP; ALS10; TDP-43; TDP43; TDP-43] |
Gene, Accession # | [TARDBP], Gene ID: 23435, NCBI: NP_031401.1, UniProt: Q13148 |
Catalog # | MBS1497439 |
Price | $120, $160 |
Order / More Info | Human TAR DNA-binding protein 43 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |