Edit |   |
---|---|
Antigenic Specificity | THEM4 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mg |
Concentration | 1 mg/mL |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The additional higher molecular weight bands seen in the immunoblot may represent post-translationally modified TMEM4. THEM4 Antibody: THEM4, also known as CTMP, binds specifically to the carboxy-terminal regulatory domain of PKB/Akt at the plasma membrane and acts as a negative regulator, reversing the phenotype of v-Akt-transformed cells. Hypermethylation of the THEM4 promoter and transcriptional downregulation of the gene has been reported in multiple glioblastomas, suggesting that epigenetic regulation of THEM4 may play a role in the progression of this cancer. Bioinformatic analysis, confirmed by in vitro testing, indicates that THEM4 is a broad-range, high activity acyl-CoA thioesterase. Recent reports have also indicated that TMEM4 i |
Immunogen | Immunogen: THEM4 antibody was raised against an 18 amino acid synthetic peptide near the center of human THEM4. Buffer: THEM4 Antibody is supplied in PBS containing 0.02% sodium azide. |
Other Names | [THEM4; CTMP; CTMP; Acyl-coenzyme A thioesterase THEM4; Carboxyl-terminal modulator protein; Acyl-CoA thioesterase THEM4; thioesterase superfamily member 4], [THEM4; THEM4; CTMP; CTMP; Acyl-CoA thioesterase THEM4] |
Gene, Accession # | [THEM4], Gene ID: 117145, NCBI: NP_444283, UniProt: Q5T1C6 |
Catalog # | MBS150493 |
Price | $375 |
Order / More Info | THEM4 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |