CASP1 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | CASP1 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Caspase-1, or interleukin-1beta converting enzyme (ICE/ICEalpha), is a class I cysteine protease, which also includes caspases-4,-5,-11, and-12. Caspase-1 cleaves inflammatory cytokines such as pro-IL-1beta and interferon-gamma inducing factor (IL-18) into their mature forms (1, 2). Like other caspases, caspase-1 is proteolytically activated from a proenzyme to produce a tetramer of its two active subunits, p20 and p10. Caspase-1 has a large amino-terminal pro-domain that contains a caspase recruitment domain (CARD). Overexpression of caspase-1 can induce apoptosis (3). Mice deficient in caspase-1, however, have no overt defects in apoptosis but do have defects in the maturation of pro-IL-1beta and are resistant to endotoxic shock (4, 5). A |
| Immunogen | Immunogen: Recombinant protein of human CASP1 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [CASP1; ICE; IL1BC; P45; Caspase-1] |
| Gene, Accession # | [CASP1], Gene ID: 834, NCBI: NP_001214.1, UniProt: P29466 |
| Catalog # | MBS8500885 |
| Price | $310 |
| Order / More Info | CASP1 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Thornberry, N.A. et al. (1992) Nature 356, 768-74. 2. Martinon, F. and Tschopp, J. (2004) Cell 117, 561-74. 3. Miura, M. et al. (1993) Cell 75, 653-60. 4. Kuida, K. et al. (1995) Science 267, 2000-3. 5. Li, P. et al. (1995) Cell 80, 401-11. 6. Feng, Q. et al. (2004) Genomics 84, 587-91. 7. Martinon, F. et al. (2002) Mol Cell 10, 417-26. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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