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Antigenic Specificity | CPLX2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: CPLX2 antibody detects endogenous levels of CPLX2. Function: Negatively regulates the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Positively regulates a late step in exocytosis of various cytoplasmic vesicles, such as synaptic vesicles and other secretory vesicles. Also involved in mast cell exocytosis (By similarity).Subunit Structure: Binds to the SNARE core complex containing SNAP25, VAMP2 and STX1A.Similarity: Belongs to the complexin/synaphin family. |
Immunogen | Immunogen: A synthesized peptide derived from human CPLX2. Subcellular Location: Cytoplasm > Cytosol. Enriched at synaptic-releasing sites in mature neurons. Tissue Specificity: Nervous system. In hippocampus and cerebellum, expressed mainly by excitatory neurons. Down-regulated in brain cortex from patients suffering from Huntington disease, bipolar disorder or major depression. Down-regulated in cerebellum from patients with schizophrenia. Predicted Cross Reactivity: |
Other Names | [921 L; Complexin 2; Complexin II; Complexin-2; Complexin2; ComplexinII; CPLX 2; Cplx2; CPLX2_HUMAN; CPX 2; CPX II; CPXII; Hfb1; Synaphin 1; Synaphin-1; Synaphin1] |
Gene, Accession # | [CPLX2], Gene ID: 10814, NCBI: NP_001008221.1, UniProt: Q6PUV4 |
Catalog # | MBS9603598 |
Price | $240, $280 |
Order / More Info | CPLX2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |