Phospho-Histone H2A.x-S139 Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Phospho-Histone H2A.x-S139 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Histone H2A.X is a variant histone that represents approximately 10% of the total H2A histone proteins in normal human fibroblasts (1). H2A.X is required for checkpoint-mediated cell cycle arrest and DNA repair following double-stranded DNA breaks (1). DNA damage, caused by ionizing radiation, UV-light, or radiomimetic agents, results in rapid phosphorylation of H2A.X at Ser139 by PI3K-like kinases, including ATM, ATR, and DNA-PK (2, 3). Within minutes following DNA damage, H2A.X is phosphorylated at Ser139 at sites of DNA damage (4). This very early event in the DNA-damage response is required for recruitment of a multitude of DNA-damage response proteins, including MDC1, NBS1, RAD50, MRE11, 53BP1, and BRCA1 (1). In addition to its role in |
| Immunogen | Immunogen: A phospho specific peptide corresponding to residues surrounding S139 of human Histone H2A.x Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [Histone H2A.x] |
| Gene, Accession # | [H2AFX], Gene ID: 3014, NCBI: NP_002096.1, UniProt: P16104 |
| Catalog # | MBS8527460 |
| Price | $310 |
| Order / More Info | Phospho-Histone H2A.x-S139 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Yuan, J. et al. (2010) FEBS Lett 584, 3717-24. 2. Rogakou, E.P. et al. (1998) J Biol Chem 273, 5858-68. 3. Burma, S. et al. (2001) J Biol Chem 276, 42462-7. 4. Rogakou, E.P. et al. (1999) J Cell Biol 146, 905-16. 5. Mukherjee, B. et al. (2006) DNA Repair (Amst) 5, 575-90. 6. Solier, S. et al. (2009) Mol Cell Biol 29, 68-82. 7. Lu, C. et al. (2006) Mol Cell 23, 121-32. 8. Lu, C. et al. (2008) FEBS Lett 582, 2703-8. 9. Cook, P.J. et al. (2009) Nature 458, 591-6. 10. Xiao, A. et al. (2009) Nature 457, 57-62. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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