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Antigenic Specificity | Phospho-PLCG2(Tyr1217) |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mL, 0.2 mL |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Phospho-PLCG2(Tyr1217) antibody detects endogenous levels of PLCG2. Function: The production of the second messenger molecules diacylglycerol (DAG) and inositol 1, 4, 5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. It is a crucial enzyme in transmembrane signaling.Subunit Structure: Interacts (via SH2 domain) with CSF1R (tyrosine phosphorylated).Post-translational Modifications: Phosphorylated on tyrosine residues by CSF1R (By similarity). Phosphorylated on tyrosine residues by BTK and SYK; upon ligand-induced activation of a variety of growth factor receptors and immune system receptors. Phosphorylation leads to increased phospholipase activity. |
Immunogen | Immunogen: A synthesized peptide derived from human PLCG2 around the phosphorylation site of Tyr1217. Subcellular Location: Cytoplasmic and Plasma Membrane |
Other Names | [1 phosphatidylinositol 4 5 bisphosphate phosphodiesterase gamma 2; 1-phosphatidylinositol-4; 5-bisphosphate phosphodiesterase gamma-2; EC 3.1.4.11; Phosphoinositide phospholipase C; Phosphoinositide phospholipase C-gamma-2; Phospholipase C gamma 2; Phospholipase C, gamma 2 (phosphatidylinositol specific); Phospholipase C-gamma-2; Phospholipase C-IV; PLC 2; PLC gamma 2; PLC IV; PLC-gamma-2; PLC-IV; Plcg2; PLCG2_HUMAN] |
Gene, Accession # | [PLCG2], Gene ID: 5336, NCBI: NP_002652.2, UniProt: P16885 |
Catalog # | MBS9600770 |
Price | $240, $280 |
Order / More Info | Phospho-PLCG2(Tyr1217) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |