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Antigenic Specificity | MPP8 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of MPP8 protein. MPHOSPH8 (M-Phase Phosphoprotein 8) is a Protein Coding gene. Heterochromatin component that specifically recognizes and binds methylated Lys-9 of histone H3 and promotes recruitment of proteins that mediate epigenetic repression. Mediates recruitment of the HUSH complex to H3K9me3 sites: the HUSH complex is recruited to genomic loci rich in H3K9me3 and is probably required to maintain transcriptional silencing by promoting recruitment of SETDB1, a histone methyltransferase that mediates further deposition of H3K9me3. Binds H3K9me and promotes DNA methylation by recruiting DNMT3A to target CpG sites; these can be situated within the coding region of the gene. Mediates down-regulation o |
Immunogen | Immunogen: Synthesized peptide derived from part region of human MPP8 protein at amino acid sequence of 290-370 |
Other Names | [Rabbit MPP8; M-phase phosphoprotein 8; Two hybrid-associated protein 3 with RanBPM; Twa3] |
Gene, Accession # | [MPP8], Gene ID: 54737, NCBI: AAH46214.1, UniProt: Q99549 |
Catalog # | MBS9709872 |
Price | $130, $220, $325 |
Order / More Info | MPP8 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |