Edit |   |
---|---|
Antigenic Specificity | TNFRSF18/Gitr Picoband |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.1 mg |
Concentration | Add 0.2ml of distilled water will yield a concentration of 500ug/ml. |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Description: Tumor necrosis factor receptor superfamily member 18 (TNFRSF18), also called GITR or AITR is a protein that in humans is encoded by the TNFRSF18 gene. It is mapped to 1p36.33. This gene encodes a member of the TNF-receptor superfamily. The encoded receptor has been shown to have increased expression upon T-cell activation, and it is thought to play a key role in dominant immunological self-tolerance maintained by CD25(+)CD4(+) regulatory T cells. Knockout studies in mice also suggest the role of this receptor is in the regulation of CD3-driven T-cell activation and programmed cell death. Three alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.Protein Function: Receptor for |
Immunogen | Immunogen: E Coli-derived human TNFRSF18 recombinant protein (Position: L178-V241). Human TNFRSF18 shares 76.2% amino acid (aa) sequence identity with mouse TNFRSF18. Subcellular Localization: Isoform 1: Cell membrane; Single-pass type I membrane protein. Tissue Specificity: Expressed in lymph node, peripheral blood leukocytes and weakly in spleen. |
Other Names | [Tumor necrosis factor receptor superfamily member 18; Activation-inducible TNFR family receptor; Glucocorticoid-induced TNFR-related protein; CD357; TNFRSF18; AITR; GITR; UNQ319/PRO364] |
Gene, Accession # | [TNFRSF18], Gene ID: 8784, NCBI: NP_004186.1, UniProt: Q9Y5U5 |
Catalog # | MBS1750813 |
Price | $280 |
Order / More Info | TNFRSF18/Gitr Picoband Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |