p63 Protein (Ab1) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | p63 Protein (Ab1) |
| Clone | polyclonal |
| Host Species | Mouse |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | unconjugated |
| Size | 5 mL |
| Concentration | n/a |
| Applications | Immunohistochemistry (IHC) Paraffin |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Clone 4A4 binds to all known Isotypes of p63. It is known as an excellent marker of basal cells in squamous epithelia and transitional cell epithelia (localisation of the antigen in cell nuclei).It is well suited for the detection of squamous cell carcinoma. In prostate tissue 80% of basal cells in benign tissue react positive, whereas p63 disappears in prostate carcinoma. The p63 gene is a homologue of the tumour suppressor gene p53. It is highly expressed in nuclei of basal cells, the progenitor cells of many epithelial tissues. It shows up remarkable structural similarities to p53. By alternative splicing at least 6 different isoforms are synthesised, which are different in the C-terminus (alpha, beta, gamma) and in the N-terminus (TA an |
| Immunogen | Immunogen: Recombinant p63 Protein (AA 1-205) N-terminal part of deltaNp63 |
| Other Names | [P63 protein; Cytoskeleton-associated protein 4; cytoskeleton-associated protein 4; cytoskeleton associated protein 4; 63-kDa cytoskeleton-linking membrane protein; Climp-63; p63], [CKAP4; CKAP4; p63; CLIMP-63; ERGIC-63; Climp-63; p63] |
| Gene, Accession # | Gene ID: 10970, NCBI: CAA49535.2, UniProt: Q07065 |
| Catalog # | MBS397321 |
| Price | $345 |
| Order / More Info | p63 Protein (Ab1) Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Yang A., Kaghard M., Wang Y., Gillett E., Fleming M.D., Dotsch V., et al. (1998) p63, a p53 homolog at 3q27-29, encodes multiple products with transactivating, death-inducing, and dominant-negative activities. Mol. Cell. 2; 305-316. 2. Celli J., Duijf P., Hamel B.C.J., Bamshad M., Kramer B., Smith A.P.T., et al. (1999) Heterozygous germline mutations in p53 homolog p63 are the cause of EEC syndrome. Cell 99; 143-153. 3. Signoretti S., Waltregny D., Dilks J., Isaak B., Lin D., Garraway L., et al. (2000) p63 is a prostate basal cell marker and is required for prostate development. Am J. Pathol. 157; 1769-1775. 4. Pelosi G., Pasini F., Stenholm C.O., Pastorino U., Maisonneuve P., Sonzogni A., et al. (2002) p63 immunoreactivity in lung cancer: yet another player in the development of squamous cell carcinomas? J. Pathol. 198; 100-109. 5. Weinstein M.H., Signoretti S., and Loda M. (2002) Diagnostic utility of immunohistochemical staining for p63, a sensitive marker of prostatic basal cells. Mod. Pathol. 15(12); 1302-1308. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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