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Antigenic Specificity | Human Histone deacetylase 3 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | caprylic acid ammonium sulfate precipitate |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Chromatin Immunoprecipitation (ChIP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Participates in the BCL6 transcriptional repressor activity by deacetylating the H3 'Lys-27' (H3K27) on enhancer elements, antagonizing EP300 acetyltransferase activity and repressing proximal gene expression. Probably participates in the regulation of transcription through its binding to the zinc-finger transcription factor YY1; increases YY1 r |
Immunogen | Immunogen: Recombinant human Histone deacetylase 3 protein(1-428aa) |
Other Names | [HD3; RPD3-2; SMAP45; HDAC3] |
Gene, Accession # | Gene ID: 8841, NCBI: NP_003874.2, UniProt: O15379 |
Catalog # | MBS7001579 |
Price | $160, $235 |
Order / More Info | Human Histone deacetylase 3 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |