caspase-9 p10 (I18) Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-caspase-9 p10 (I18) antibody, protein, ELISA kits.
| Edit | |
|---|---|
| Antigenic Specificity | caspase-9 p10 (I18) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | mouse, rat, human |
| Isotype | n/a |
| Format | unconjugated |
| Size | 0.2 mg |
| Concentration | 0.200 mg/ml |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | Specificity: Mouse, rat, and human caspase-9 p10 and caspase-9 precursor. The activation of the initiator caspase, caspase-9, is regulated by the apoptosome, which is composed of cytochrome c bound to Apaf-1 and dATP (1&2). The apoptosome responds to a diverse array of apoptotic stimuli that initiate the caspase cascade that ultimately results in cell death. The cascade of events starts with the proteolytic cleavage of caspase-9, that then cleaves downstream caspases, caspase-3, -6, and '7 (1). The apoptotic initiating activity of caspase-9 can be regulated by XIAP, X-linked inhibitor-of-apoptosis protein; through the binding of caspase-9 at it amino terminus while it is bound to the apoptosome (3 & 4). This inhibition of caspase-9 activity |
| Immunogen | Immunogen: Synthetic peptide mapping to an internal domain within the p10 subunit of human caspase-9 |
| Other Names | n/a |
| Gene, Accession # | n/a |
| Catalog # | MBS440070 |
| Price | $240 |
| Order / More Info | caspase-9 p10 (I18) Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Kuida K. 2000. Caspase-9. Int J Biochem Cell Biol. 32(2):121-124.2. Potokar M, Milisav I, Kreft M, Stenovec M, Zorec R. 2003. Apoptosis triggered redistribution of caspase-9 from cytoplasm to mitochondria. FEBS Lett. 544(1-3):153-159.3. Srinivasula SM, Hegde R, Saleh A, Datta P, Shiozaki E, Chai J, Lee RA, Robbins PD, Fernandes-Alnemri T, Shi Y, Alnemri ES. 2001. A conserved XIAP-interaction motif in caspase-9 and Smac/DIABLO regulates caspase activity and apoptosis. Nature 410(6824):112-116.4. Zou H, Yang R, Hao J, Wang J, Sun C, Fesik SW, Wu JC, Tomaselli KJ, Armstrong RC. 2003. Regulation of the Apaf-1/caspase-9 apoptosome by caspase-3 and XIAP. J Biol Chem. 278(10):8091-8098. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
Profile of MYBIOSOURCE INC.
Return to Antibodies