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Antigenic Specificity | CDK12 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | Protein G purified |
Size | 0.05 mg, 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Cyclin-dependent kinase that phosphorylates the C-terminal domain (CTD) of the large subunit of RNA polymerase II (POLR2A), thereby acting as a key regulator of transcription elongation. Regulates the expression of genes involved in DNA repair and is required for the maintenance of genomic stability. Preferentially phosphorylates 'Ser-5' in CTD repeats that are already phosphorylated at 'Ser-7', but can also phosphorylate 'Ser-2'. Required for RNA splicing, possibly by phosphorylating SRSF1/SF2. Involved in regulation of MAP kinase activity, possibly leading to affect the response to estrogen inhibitors. |
Immunogen | Immunogen: Recombinant Human Cyclin-dependent kinase 12 protein (1309-1490AA) |
Other Names | [Cyclin-dependent kinase 12; Cdc2-related kinase; arginine/serine-rich; CrkRS; Cell division cycle 2-related protein kinase 7; CDC2-related protein kinase 7; Cell division protein kinase 12; hCDK12; CDK12; CRK7; CRKRS; KIAA0904] |
Gene, Accession # | [CDK12], Gene ID: 51755, NCBI: NP_055898.1, UniProt: Q9NYV4 |
Catalog # | MBS7108675 |
Price | $160, $235 |
Order / More Info | CDK12 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |