Edit |   |
---|---|
Antigenic Specificity | PRKCB |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Calcium-activated, phospholipid-and diacylglycerol (DAG)-dependent serine/threonine-protein kinase involved in various cellular processes such as regulation of the B-cell receptor (BCR) signalosome, oxidative stress-induced apoptosis, androgen receptor-dependent transcription regulation, insulin signaling and endothelial cells proliferation. Plays a key role in B-cell activation by regulating BCR-induced NF-kappa-B activation. Mediates the activation of the canonical NF-kappa-B pathway (NFKB1) by direct phosphorylation of CARD11/CARMA1 at 'Ser-559', 'Ser-644' and 'Ser-652'. Phosphorylation induces CARD11/CARMA1 association with lipid rafts and recruitment of the BCL10-MALT1 complex as well as MAP3K7/TAK1, which then activates IKK complex, r |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 1-270 of human PRKCB (NP 002729.2). |
Other Names | [PKCB; PRKCB1; PRKCB2; PKCI(2; PKCbeta; PKC-beta] |
Gene, Accession # | [PRKCB], Gene ID: 5579, NCBI: NP_002729.2, UniProt: P05771 |
Catalog # | MBS8549143 |
Price | $280 |
Order / More Info | PRKCB Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |