Edit |   |
---|---|
Antigenic Specificity | GAD2, 109-138 |
Clone | [458CT17.2.4] |
Host Species | Mouse |
Reactive Species | human, rat (predicted reactivity: mouse, porcine) |
Isotype | IgG1 |
Format | ascites |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This GAD2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 109-138 amino acids from human GAD2. This gene encodes one of several forms of glutamic aciddecarboxylase, identified as a major autoantigen ininsulin-dependent diabetes. The enzyme encoded is responsible forcatalyzing the production of gamma-aminobutyric acid fromL-glutamic acid. A pathogenic role for this enzyme has beenidentified in the human pancreas since it has been identified as anautoantibody and an autoreactive T cell target in insulin-dependentdiabetes. This gene may also play a role in the stiff man syndrome.Alternative splicing results in multiple transcript variants thatencode the same protein. |
Immunogen | n/a |
Other Names | [Glutamate decarboxylase 2; 65 kDa glutamic acid decarboxylase; GAD-65; Glutamate decarboxylase 65 kDa isoform; GAD2; GAD65] |
Gene, Accession # | [GAD2], Gene ID: 2572, NCBI: NP_000809.1, UniProt: Q05329 |
Catalog # | MBS9200406 |
Price | $370 |
Order / More Info | GAD2, 109-138 Antibody from MYBIOSOURCE INC. |
Product Specific References | Bailey, S.D., et al. Diabetes Care 33(10):2250-2253(2010) Jia, P., et al. Schizophr. Res. 122 (1-3), 38-42 (2010) : Ruano, G., et al. Pharmacogenomics 11(7):959-971(2010) Pinheiro, A.P., et al. Am. J. Med. Genet. B Neuropsychiatr. Genet. 153B (5), 1070-1080 (2010) : Jugessur, A., et al. PLoS ONE 5 (7), E11493 (2010) : |