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Antigenic Specificity | Rag A/B |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.03 mL, 0.1 mL, 0.2 mL |
Concentration | 1 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) Paraffin, ELISA (EIA) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Rag A/B Polyclonal Antibody detects endogenous levels of Rag A/B protein. Has guanine nucleotide-binding activity but undetectable intrinsic GTPase activity. Required for the amino acid-induced relocalization of mTORC1 to the lysosomes and its subsequent activation by the GTPase RHEB. This is a crucial step in the activation of the TOR signaling cascade by amino acids. Involved in the RCC1/Ran-GTPase pathway. May play a direct role in a TNF-alpha signaling pathway leading to induction of cell death. May alternatively act as a cellular target for adenovirus E3-14. K, an inhibitor of TNF-alpha functions, thereby affecting cell death. |
Immunogen | Immunogen: Synthesized peptide derived from the C-terminal region of human Rag A/B at AA range: 240-320 |
Other Names | [Rabbit Rag A/B; Ras-related GTP-binding protein A; Rag A; RagA; Adenovirus E3 14.7 kDa-interacting protein 1; FIP-1; RRAGB; Ras-related GTP-binding protein B; Rag B; RagB] |
Gene, Accession # | [RRAGA], Gene ID: 10670, UniProt: Q7L523 |
Catalog # | MBS9702996 |
Price | $130, $220, $325 |
Order / More Info | Rag A/B Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |