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Antigenic Specificity | CCND1 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mg |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: Western blot analysis of extracts of HeLa cell line, using CCND1 antibody. Immunohistochemistry of paraffin-embedded human epididymis using CCND1 antibody at dilution of 1:500 (400x lens). Activity of the cyclin-dependent kinases CDK4 and CDK6 is regulated by T-loop phosphorylation, by the abundance of their cyclin partners (the D-type cyclins), and by association with CDK inhibitors of the Cip/Kip or INK family of proteins (1). The inactive ternary complex of cyclin D/CDK4 and p27 Kip1 requires extracellular mitogenic stimuli for the release and degradation of p27 concomitant with a rise in cyclin D levels to affect progression through the restriction point and Rb-dependent entry into S-phase (2). The active complex of cyclin |
Immunogen | Immunogen: Recombinant protein of human Cyclin D1 |
Other Names | [CCND1, partial; G1/S-specific cyclin-D1; G1/S-specific cyclin-D1; cyclin D1; B-cell lymphoma 1 protein; BCL-1; BCL-1 oncogene; PRAD1 oncogene], [CCND1; CCND1; BCL1; PRAD1; U21B31; D11S287E; BCL1; PRAD1; BCL-1] |
Gene, Accession # | [CCND1], Gene ID: 595, NCBI: CAG46896.1 |
Catalog # | MBS419645 |
Price | $385 |
Order / More Info | CCND1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |