Insulin Receptor beta Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Insulin Receptor beta |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | FMS-related tyrosine kinase 3 (FLT3, also called Flk2), is a member of the type III receptor tyrosine kinase family, which includes c-Kit, PDGFR and M-CSF receptors. FLT3 is expressed on early hematopoietic progenitor cells and supports growth and differentiation within the hematopoietic system (1, 2). FLT3 is activated after binding with its ligand FL, which results in a cascade of tyrosine autophosphorylation and tyrosine phosphorylation of downstream targets (3). The p85 subunit of PI3 kinase, SHP2, GRB2 and Shc are associated with FLT3 after FL stimulation (4-6). Tyr589/591 is located in the juxtamembrane region of FLT3 and may play an important role in regulation of FLT3 tyrosine kinase activity. Somatic mutations of FLT3 consisting of |
| Immunogen | Immunogen: Fusion protein of human FLT3. Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [FLT3; CD135; FLK2; STK1], [FLT3; FLT3; FLK2; STK1; CD135; FLK-2; CD135; FLK2; STK1; FLK-2; FLT-3; STK-1] |
| Gene, Accession # | [INSR], Gene ID: 2322, NCBI: NP_004110.2, UniProt: P36888 |
| Catalog # | MBS857297 |
| Price | $290 |
| Order / More Info | Insulin Receptor beta Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Shurin, M.R. et al. (1998) Cytokine Growth Factor Rev. 9, 37-48. 2. Naoe, T. et al. (2001) Cancer Chemother. Pharmacol. 48 Suppl1, S27-S30. 3. Namikawa, R. et al. (1996) Stem Cells 14, 388-395. 4. Beslu, N. et al. (1996) J. Biol. Chem. 271, 20075-20081. 5. Zhang, S. and Broxmeyer, H.E. (2000) Biochem. Biophys. Res. Commun. 277, 195-199. 6. Zhang, S. et al. (1999) J. Leukoc. Biol. 65, 372-380. 7. Mizuki, M. et al. (2000) Blood 96, 3907-3914. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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