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Antigenic Specificity | TRIP12 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | peptide affinity purified |
Size | 0.1 mg |
Concentration | 1 mg/mL |
Applications | ELISA (EIA), Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Specificity: TRIP12 antibody is human, mouse and rat reactive. At least four isoforms are known to exist. Thyroid hormone receptors (TRs) are transcription factors that regulate the expression of specific genes in a hormone-dependent manner (1). TRIP12 (thyroid hormone receptor interactor 12) is an ATP-dependent E3 ubiquitin ligase involved in the human ubiquitin fusion degradation (UFD) pathway and also modulates the NEDD8 pathway (2,3). TRIP12 contains one WWE domain and a single HECT (E6AP-type E3 ubiquitin-protein ligase) domain suggested to contain a noncovalent ubiquitin-binding site (4). TRIP12 acts as a key regulator of DNA damage response and the ubiquitin ligase activity of TRIP12 is essential for mouse development (5). |
Immunogen | Immunogen: TRIP12 antibody was raised against a 18 amino acid peptide near the carboxy terminus of human TRIP12. Buffer: TRIP12 antibody is supplied in PBS containing 0.02% sodium azide. |
Other Names | [TRIP12; ULF; TRIP-12; KIAA0045; ULF; E3 ubiquitin-protein ligase TRIP12; E3 ubiquitin-protein ligase for Arf; Thyroid hormone receptor interactor 12], [TRIP12; TRIP12; ULF; TRIP-12; KIAA0045; ULF; ULF; TR-interacting protein 12; TRIP-12] |
Gene, Accession # | [TRIP12], Gene ID: 9320, NCBI: NP_004229, UniProt: Q14669 |
Catalog # | MBS153608 |
Price | $375 |
Order / More Info | TRIP12 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |