MAPK7 Antibody from MYBIOSOURCE INC.
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| Edit | |
|---|---|
| Antigenic Specificity | MAPK7 |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | ERK5 (Mitogen-activated protein kinase 7, Big mitogen-activated protein kinase 1) is a member of the MAPK superfamily implicated in the regulation numerous cellular processes including proliferation, differentiation, and survival (1, 5-7). Like other MAPK family members, ERK5 contains a canonical activation loop TEY motif (Thr218/Tyr220) which is specifically phosphorylated by MAP2K5 (MEK5) in a growth factor-dependent, Ras-independent mechanism (2-4). For example, EGF stimulation promotes ERK5 phosphorylation which induces its traslocation to the nucleus where it phosphorylates MEF2C and other transcriptional targets (2, 3). ERK5 is also activated in response to granulocyte colony-stimulating factor (G-CSF) in hematopoetic progenitor cells |
| Immunogen | Immunogen: Recombinant protein of human MAPK7 Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [BMK1; ERK4; ERK5; PRKM7] |
| Gene, Accession # | [MAPK7], Gene ID: 5598, NCBI: NP_002740.2, UniProt: Q13164 |
| Catalog # | MBS8504461 |
| Price | $310 |
| Order / More Info | MAPK7 Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Zhou, G. et al. (1995) J Biol Chem 270, 12665-9. 2. Kato, Y. et al. (1998) Nature 395, 713-6. 3. Kato, Y. et al. (1997) EMBO J 16, 7054-66. 4. Dong, F. et al. (2001) J Biol Chem 276, 10811-6. 5. Hayashi, M. and Lee, J.D. (2004) J Mol Med 82, 800-8. 6. Wang, X. and Tournier, C. (2006) Cell Signal 18, 753-60. 7. Nishimoto, S. and Nishida, E. (2006) EMBO Rep 7, 782-6. 8. Spiering, D. et al. (2009) J Biol Chem, . 9. Sawhney, R.S. et al. (2009) J Cell Physiol 219, 152-61. 10. Zhao, Z. et al. (2009) Mol Cell Biochem 322, 171-8. 11. Obara, Y. et al. (2009) J Biol Chem, . 12. Finegan, K.G. et al. (2009) Cell Death Differ 16, 674-83. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
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San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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