BTRC Antibody from MYBIOSOURCE INC.
Search, find, compare suppliers for anti-BTRC antibody, protein, ELISA kits.
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|---|---|
| Antigenic Specificity | BTRC |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse, rat |
| Isotype | n/a |
| Format | affinity purified |
| Size | 0.1 mL |
| Concentration | n/a |
| Applications | Western Blot (WB), Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | beta-transducin repeat-containing protein (beta-TrCP or FBW1A) is an F-box family protein characterized by the presence of the protein-protein mediating F-box domain first described in cyclin F. F-box proteins act as substrate adaptors that target proteins containing a specific phosphorylated sequence element, referred to as a phosphodegron, to the SCF E3 ubiquitin ligase complex for ubiquitination (1, 2). beta-TrCP targets many important proteins with diverse functions, such as p53, H-Ras, Smad4, IkappaBalpha, beta-catenin, and the cell cycle checkpoint protein claspin, for ubiquitin-mediated degradation (3-5). Research studies have shown that inhibition of beta-TrCP expression has a demonstrated benefit in the treatment of prostate cancer |
| Immunogen | Immunogen: Recombinant protein of human BTRC Storage Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3. |
| Other Names | [BETA-TRCP; FBW1A; FBXW1; FBXW1A; FWD1; MGC4643; bTrCP; bTrCP1; betaTrCP] |
| Gene, Accession # | [BTRC], Gene ID: 8945, NCBI: NP_003930.1, UniProt: Q9Y297 |
| Catalog # | MBS8501053 |
| Price | $310 |
| Order / More Info | BTRC Antibody from MYBIOSOURCE INC. |
| Product Specific References | 1. Bour, S. et al. (2001) J Biol Chem 276, 15920-8. 2. Kusmierczyk, A.R. and Hochstrasser, M. (2008) Biol Chem 389, 1143-51. 3. Wan, M. et al. (2004) J Biol Chem 279, 14484-7. 4. Mailand, N. et al. (2006) Mol Cell 23, 307-18. 5. Frescas, D. and Pagano, M. (2008) Nat Rev Cancer 8, 438-49. 6. Gluschnaider, U. et al. (2010) PLoS One 5, e9060. |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
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http://www.MyBioSource.com
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