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Antigenic Specificity | DC-SIGN, Human |
Clone | DCN47.5 |
Host Species | Mouse |
Reactive Species | human |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.1 mg |
Concentration | n/a |
Applications | Flow Cytometry (FC/FACS), FS |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Product Description: The monoclonal antibody DCN47.5 reacts with the C-type lectin, DC-SIGN (CD209), exclusively expressed on human dendritic cells (DC). DC are specialized antigen presenting cells and bridge the innate and the adaptive immune system. They provide high levels of costimulation necessary for activation of both na ve and antigen-experienced T-cells. Immature DC are capable to migrate to inflammatory sites, capture antigen and process it internally to form MHC-peptide complexes. Following antigen uptake, DC undergo maturation and migrate to lymphoid organs where they can present MHC-peptide complexes to resting T-cells and drive T-cell proliferation. During differentiation and maturation of DC, several phenotypic surface marker |
Immunogen | n/a |
Other Names | [DC-SIGN; CD209 antigen; CD209 antigen; HIV gpl20-binding protein; C-type lectin domain family 4 member L; C-type lectin domain family 4, member L; dendritic cell-specific ICAM-3-grabbing non-integrin 1; dendritic cell-specific intracellular adhesion molecules (ICAM)-3 grabbing non-integrin; CD209 molecule; C-type lectin domain family 4 member L; Dendritic cell-specific ICAM-3-grabbing non-integrin 1; DC-SIGN; DC-SIGN1; CD_antigen: CD209], [CD209; CD209; CDSIGN; CLEC4L; DC-SIGN; DC-SIGN1; CLEC4L; DC-SIGN; DC-SIGN1] |
Gene, Accession # | [DC-SIGN], Gene ID: 30835, NCBI: AAK20997.1 |
Catalog # | MBS584034 |
Price | $610 |
Order / More Info | DC-SIGN, Human Antibody from MYBIOSOURCE INC. |
Product Specific References | Whelan, K et al; The HIV protease inhibitor Indinavir reduces immature dendritic cell transendothelial migration. Eur J Immunol 2003, 33: 2520 |