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Antigenic Specificity | p14 ARF |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | immunogen affinity purified |
Size | 0.05 mL, 0.1 mL |
Concentration | 1.0 mg/ml |
Applications | Western Blot (WB), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The antibody detects endogenous levels of total p14 ARF protein. Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates |
Immunogen | Immunogen Type: Peptide Immunogen Description: Synthesized peptide derived from human p14 ARF antibody. |
Other Names | [CDK4I; CMM2; MLM; MTS1; TP16] |
Gene, Accession # | [p14 ARF], Gene ID: 1029, NCBI: NP_478102.2, UniProt: Q8N726 |
Catalog # | MBS9411770 |
Price | $200, $255 |
Order / More Info | p14 ARF Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |