Trk A (Phospho-Tyr757) Antibody from MYBIOSOURCE INC.
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| Antigenic Specificity | Trk A (Phospho-Tyr757) |
| Clone | polyclonal |
| Host Species | Rabbit |
| Reactive Species | human, mouse |
| Isotype | n/a |
| Format | epitope affinity purified |
| Size | 0.05 mL, 0.1 mL |
| Concentration | 1.0 mg/ml |
| Applications | Immunohistochemistry (IHC) |
| Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
| Description | The antibody detects endogenous levels of Trk A only when phosphorylated at tyrosine 757. Required for high-affinity binding to nerve growth factor (NGF), neurotrophin-3 and neurotrophin-4/5 but not brain-derived neurotrophic factor (BDNF). Known substrates for the Trk receptors are SHC1, PI 3-kinase, and PLC-gamma-1. Has a crucial role in the development and function of the nociceptive reception system as well as establishment of thermal regulation via sweating. Activates ERK1 by either SHC1- or PLC-gamma-1-dependent signaling pathway.Martin-Zanca D., Mol. Cell. Biol. 9:24-33(1989).Shelton D.L., J. Neurosci. 15:477-491(1995).The MGC Project Team, Genome Res. 14:2121-2127(2004). |
| Immunogen | Immunogen Type: Peptide-KLH Immunogen Description: Peptide sequence around phosphorylation site of tyrosine 757 (E-V-Y(p)-A-I) derived from Human Trk A. |
| Other Names | [TRKA; TRK; NTRK1; p140-TrkA] |
| Gene, Accession # | [Trk A], Gene ID: 4914, NCBI: NP_001007793.1, UniProt: P04629 |
| Catalog # | MBS9403981 |
| Price | $200, $255 |
| Order / More Info | Trk A (Phospho-Tyr757) Antibody from MYBIOSOURCE INC. |
| Product Specific References | n/a |
MYBIOSOURCE INC.
MYBIOSOURCE INC.
P.O. Box 153308
San Diego CA 92195-3308
P: 1.858.633.0165
P: 1.888.MBS.0165 (1.888.627.0165) (US & Canada)
F: 1.858.633.0166
sales@mybiosource.com
http://www.MyBioSource.com
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