Edit |   |
---|---|
Antigenic Specificity | Phospho-CrkII (Tyr221) |
Clone | monoclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | affinity purified |
Size | 0.03 mg, 0.1 mg, 0.1 mg |
Concentration | n/a |
Applications | Immunofluorescence (IF), Immunocytochemistry (ICC), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | The Crk-I and Crk-II forms differ in their biological activities. Crk-II has less transforming activity than Crk-I. Crk- II mediates attachment-induced MAPK8 activation, membrane ruffling and cell motility in a Rac-dependent manner. Involved in phagocytosis of apoptotic cells and cell motility via its interaction with DOCK1 and DOCK4. May regulate the EFNA5-EPHA3 signaling. |
Immunogen | Immunogen: A synthesized peptide derived from human Phospho-CrkII (Tyr221) Subcellular Localization: Cytoplasm. Cell membrane. Translocated to the plasma membrane upon cell adhesion. |
Other Names | [Adapter molecule crk; Proto-oncogene c-Crk; p38; CRK] |
Gene, Accession # | [CrkII], Gene ID: 1398, NCBI: NP_005197.3, UniProt: P46108 |
Catalog # | MBS1750274 |
Price | $160, $340, $340 |
Order / More Info | Phospho-CrkII (Tyr221) Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |