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Antigenic Specificity | F8 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse, rat |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Immunohistochemistry (IHC) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This gene encodes coagulation factor VIII, which participates in the intrinsic pathway of blood coagulation; factor VIII is a cofactor for factor IXa which, in the presence of Ca+2 and phospholipids, converts factor X to the activated form Xa. This gene produces two alternatively spliced transcripts. Transcript variant 1 encodes a large glycoprotein, isoform a, which circulates in plasma and associates with von Willebrand factor in a noncovalent complex. This protein undergoes multiple cleavage events. Transcript variant 2 encodes a putative small protein, isoform b, which consists primarily of the phospholipid binding domain of factor VIIIc. This binding domain is essential for coagulant activity. Defects in this gene results in hemophilia |
Immunogen | Immunogen: Recombinant protein of human F8 (NP 063916.1). |
Other Names | [coagulation factor VIII isoform a preproprotein; Coagulation factor VIII; coagulation factor VIII; coagulation factor VIII; Antihemophilic factor; AHF; Procoagulant component] |
Gene, Accession # | [F8], Gene ID: 2157, NCBI: NP_000123.1, UniProt: P00451 |
Catalog # | MBS8568684 |
Price | $280 |
Order / More Info | F8 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |