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Antigenic Specificity | U2AF2 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB), Immunofluorescence (IF), Immunoprecipitation (IP) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Necessary for the splicing of pre-mRNA. By recruiting PRPF19 and the PRP19C/Prp19 complex/NTC/Nineteen complex to the RNA polymerase II C-terminal domain (CTD), and thereby pre-mRNA, may couple transcription to splicing (PubMed:21536736). Induces cardiac troponin-T (TNNT2) pre-mRNA exon inclusion in muscle. Regulates the TNNT2 exon 5 inclusion through competition with MBNL1. Binds preferentially to a single-stranded structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Required for the export of mRNA out of the nucleus, even if the mRNA is encoded by an intron-less gene. Represses the splicing of MAPT/Tau exon 10. |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 192-471 of human U2AF2 (NP 001012496.1). |
Other Names | [U2AF65] |
Gene, Accession # | [U2AF2], Gene ID: 11338, NCBI: P26368.4, UniProt: P26368 |
Catalog # | MBS8544681 |
Price | $280 |
Order / More Info | U2AF2 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |