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Antigenic Specificity | Caspase 7 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human |
Isotype | n/a |
Format | epitope affinity purified |
Size | 0.1 mg |
Concentration | n/a |
Applications | ELISA (EIA), Flow Cytometry (FC/FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | This antibody recognizes ~35 kDa of human Caspase 7. The other species are not tested. Caspase-7 belongs to a member of the cysteine-aspartic acid protease (Caspase) family. Sequential activation of caspases plays a central role in the execution-phase of cell apoptosis. Caspases exist as inactive proenzymes which undergo proteolytic processing at conserved aspartic residues to produce two subunits, large and small. Those dimerize to form the active enzyme. The precursor of this caspase is cleaved by Caspase 3 and 10. It is activated upon cell death stimuli and induces apoptosis. Caspase-7 (CMH-1, Mch3, ICE-LAP3) has been identified as a major contributor to the execution of apoptosis. It is cleaved by many enzymes, including caspases-3, -6, |
Immunogen | n/a |
Other Names | [Caspase-7; CASP7; ICE-IAP3; CMH-1; MCH3], [casp7] |
Gene, Accession # | Gene ID: 100198668, NCBI: NP_001267753.1 |
Catalog # | MBS460133 |
Price | $285 |
Order / More Info | Caspase 7 Antibody from MYBIOSOURCE INC. |
Product Specific References | Lippke, J. A et al. Identification and characterization of CPP32/MCH2 homolog 1, a novel cysteine protease similar to CPP32. J. Biol. Chem. 271 (4), 1825-1828 (1996). |