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Antigenic Specificity | MAPK10 |
Clone | polyclonal |
Host Species | Rabbit |
Reactive Species | human, mouse |
Isotype | n/a |
Format | affinity purified |
Size | 0.1 mL |
Concentration | n/a |
Applications | Western Blot (WB) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK10/JNK3. In turn, MAPK10/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in th |
Immunogen | Immunogen: Recombinant fusion protein containing a sequence corresponding to amino acids 175-464 of human MAPK10 (NP 620448.1). |
Other Names | [JNK3; JNK3A; PRKM10; SAPK1b; p493F12; p54bSAPK] |
Gene, Accession # | [MAPK10], Gene ID: 5602, NCBI: NP_002744.1, UniProt: P53779 |
Catalog # | MBS8544806 |
Price | $280 |
Order / More Info | MAPK10 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |