Edit |   |
---|---|
Antigenic Specificity | PINK1 |
Clone | [S4-15] |
Host Species | Mouse |
Reactive Species | human, rat, mouse |
Isotype | IgG1 |
Format | unconjugated |
Size | 0.1 mg |
Concentration | 1mg/ml |
Applications | Western Blot (WB), Immunocytochemistry (ICC), Immunohistochemistry (IHC), Immunofluorescence (IF) |
Reviews / Ratings | If you have used this antibody, please help fellow researchers by submitting reviews to pAbmAbs and antYbuddY. |
Description | Detects ~50kDa. Background Info: Detects a 50 kDa protein corresponding to the molecular weight of PINK1 Scientific Background: PINK1 (PTEN induced putative kinase 1) is a mitochondrial serine/threonine kinase which maintains mitochondrial function/integrity, provides protection against mitochondrial dysfunction during cellular stress, potentially by phosphorylating mitochondrial proteins, and is involved in the clearance of damaged mitochondria via selective autophagy (mitophagy). PINK1 is synthesized as a 63 kD protein which undergoes proteolyt processing to generate at least two cleaved forms (55 kD and 42 kD). PINK1 and its substrates have been found in the cytosol as well as in different sub-mitochondrial compartments, and according to |
Immunogen | Immunogen: Fusion protein amino acids 112-496 (cytoplasmic C-terminus) of human PINK1. 82% identical to rate and 81% identical to mouse. >30% identity with DMPK. |
Other Names | [Parkinson disease (autosomal recessive) 6; EC 2.7.11.1; PARK6; serine/threonine-protein kinase PINK1 mitochondrial; PTEN-induced putative kinase protein 1; protein kinase BRPK; BRPK; FLJ27236; PTEN induced putative kinase 1; Phosphatase and Tensin Homolog], [PINK1; PINK1; BRPK; PARK6] |
Gene, Accession # | Gene ID: 65018, NCBI: NP_115785.1, UniProt: Q9BXM7 |
Catalog # | MBS800448 |
Price | $390 |
Order / More Info | PINK1 Antibody from MYBIOSOURCE INC. |
Product Specific References | n/a |